A Trick that Helps Horses and Cattle Avoid Metastatic Cancer

Researchers find connective tissue has a crucial role to play in whether cancer cells metastasize.

ABOVE:  Cow trophoblasts (green) invade a layer of human stromal cells (black), which may also be susceptible to metastasizing cancer cells.


The paper
Kshitiz et al., “Evolution of placental invasion and cancer metastasis are causally linked,” Nat Ecol Evol, 3:1743–53, 2019.

The study was conceived like a cliché joke: an evolutionary biologist, a cell-signaling specialist, and a cancer researcher walk into a happy hour at Yale University. The conversation turned to mammalian tumors, and how it was common to see horses in Austria and cows in India with prominent tumors that rarely killed the animals.

It turns out that horses and cows have something else in common. “Interestingly, in the same animals, the pregnancy is very different from human pregnancy,” says the University of Connecticut Health Center’s Kshitiz, the cancer researcher, who uses a single name. Placental cells in ungulates don’t burrow into the uterine lining early in pregnancy as they do in apes and many other mammals….

Source: A Trick that Helps Horses and Cattle Avoid Metastatic Cancer

You could tell here, how to insert the OWN Awatar here!

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s